B8385
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B8385
Sigma
Bestatin hydrochloride
≥98% (HPLC)
| Synonym: | N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]- |
| CAS Number: | 65391-42-6 |
| Linear Formula: | C16H24N2O4 · HCl |
| Molecular Weight: | 344.83 |
| Beilstein Registry Number: | 4628066 |
| MDL number: | MFCD00058004 |
| PubChem Substance ID: | 24278278 |
Description
| Preparation Note | Solubility testing in water at 25 mg/ml yields a clear solution. Stock solutions at 1 mM are expected to be stable at least one month stored at -20 °C. |
| Biochem/physiol Actions | A metalloprotease inhibitor selective for aminopeptidase. Bestatin is a competitive and specific inhibitor of leucine aminopeptidase, aminopeptidase B, and triamino peptidase. It inhibits aminopeptidase B at 60 nM (using arginine-β-naphthylamide as substrate) and leucine aminopeptidase at 20 nM (leucine-β-naphthylamide as substrate). It showed no inhibition of aminopeptidase A, trypsin, chymotrypsin, elastase, papain, pepsin, or themolysin. |
Properties
| assay | ≥98% (HPLC) |
| EQP level | Premium |
| storage temp. | −20°C |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
References
| reference | Taylor, A., FASEB J. 7, 290-298, (1993) Abstract |
| Umezawa, H., et al. J. Antibiot. 29, 97,100-99,101, (1976) |
